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BioFlo^® 510

SIP benchtop reactors designed to meet the needs of R&D through production. More information

Product Information

The BioFlo 510 is a compact sterilizable-in-place fermentation system ideal for pilot to small scale production processes. The modular design features a wide variety of standard options allowing this system to be flexible enough to meet most process requirements.

Gas flow
› Various combinations of one, two, three or four TMFCs:
0.06  –  3 SLPM
0.3  –  15 SLPM
0.6  –  32 SLPM
1  –  64 SLPM
› Overlay (valve only)

Exhaust line
› Exhaust condenser
› Manual or automatic pressure control

Impellers
› Rushton-type – Used commonly for robust cell lines such as bacteria, yeasts, and algae, where maximum OTR is desired. Provided as standard on BioFlo 510 fermentors
› Pitched-blade – Commonly used with mammalian, insect or other shear sensitive cell lines for batch, fed-batch or continuous cultures. Produces axial and radial mixing.
› Marine – Commonly used with mammalian, insect, or other shear sensitive cell lines for batch, fed-batch or continuous cultures. Produces axial mixing

Sensors
› Single or redundant pH/DO
› Redox
› Foam/level

Addition and sampling
› Resterilizable sampling valve
› Resterilizable addition valves (4 max)
› Resterilizable addition/harvest valve with dip tube (2 max)
› 1.5 in sanitary fitting 7-port septum
› Addition vessels (glass/stainless steel)
› Sterile sampling assembly

Validation
› Basic Package
› Basic Plus Package
› Enhanced Package

Utility regulator & pre-filter kits
› Process air pre-filter/regulator kit
› Instrument air pre-filter/regulator kit
› Water pre-filter/regulator kit
› Process steam regulator kit
› Utility steam pre-filter/regulator kit
› Utility connection kit

Additional options
› Sprayballs for clean-in-place of vessel
› External variable-speed pumps
› External scales
› Spare parts kits
› Preventive maintenance kits
› Mobile table
› System passivation
› Glycol/chiller heat exchanger

Features

RPC (Reactor Process Control) software
32.0 L working volume stainless-steel electropolished vessels with 2:1 aspect ratios
Integrated load cell
3-fixed speed peristaltic pumps for the additions, harvest and pH control
Benchtop or Mobile option
Includes Rushton-type impellers with pitched-blade and marine blade option
Industrial touchscreen interface

Applications

Laboratory- and pilot-scale fermentation of aerobic and anaerobic bacteria, yeasts, and fungi
Laboratory- and pilot-scale cell culture of mammalian, insect, and human cell lines
Special applications such as stem cell culture, vaccine, monoclonal antibody or biofuel/biopolymer production
Suitable for batch, fed-batch, and continuous/perfusion processes